Fig. 8: DPEP1 and CHMP1A levels correlate and associated with ferroptosis gene expression in human kidney samples. | Nature Communications

Fig. 8: DPEP1 and CHMP1A levels correlate and associated with ferroptosis gene expression in human kidney samples.

From: A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

Fig. 8

a Relative expression of DPEP1 (y-axis) and CHMP1A (x-axis) in 432 microdissected human kidney tubule samples. Pearson correlation is shown. Student t-test based on the Pearson correlation coefficient was used to calculate the statistical significance of the association. b Genes showing significant correlation with DPEP1 and CHMP1A in microdissected human kidney tubule samples. y-axis represents the Pearson correlation P value. c Relative transcript levels of ACSL4, ACSL3, and SLC3A2 (FPKM, y-axis), and kidney function (eGFR, x-axis) or kidney fibrosis (x-axis) as analyzed in 432 microdissected human kidney samples. Pearson correlation is shown. Student’s t-test based on the Pearson correlation coefficient was used to calculate the statistical significance of the association. d Representative images of ACSL4 immunostaining in healthy control and CKD kidney samples. Scale bar: 20 μm. e Western blots of ACSL4 in healthy control and CKD kidney samples.

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