Fig. 3: Results of SMR based integration analysis of DPW and AUD GWAS meta-analysis with eQTL/mQTL from fetal and adult brain. | Nature Communications

Fig. 3: Results of SMR based integration analysis of DPW and AUD GWAS meta-analysis with eQTL/mQTL from fetal and adult brain.

From: Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

Fig. 3

X-axis represents the chromosomes and Y-axis shows the standardized direction of effect (Z scores) of co-localized SNP on gene expression/ methylation and GWAS phenotype. Z scores were derived from the effect size (betas) and standard errors (SE) from the SMR analyses. Positive Z score shows that increase in mRNA expression or methylation is associated with excessive drinking or increased risk of AUD, while negative Z score depicts the vice-versa. Genes marked on the plots represent the genes that passed the strict threshold of co-localization (FDR SMR-P < 20%; SMRHeidi P > 0.05; GWAS P < 5 × 10−5; eQTL P < 5 × 10−8) and multiple levels of transcriptomic and/ or epigenetic evidence. SMR P-values for the co-localized SNPs are obtained using the Wald test.

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