Fig. 4: MAPT was identified as a candidate gene associated with increased DPW. | Nature Communications

Fig. 4: MAPT was identified as a candidate gene associated with increased DPW.

From: Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

Fig. 4

A Locus zoom plot showing DPW and eQTL (DLFPC) associations at 17q.21.3. X-axis represents the positions along chromosome 17 and the y-axis represents the P values of each SNP at this locus. P-values for the DPW GWAS are obtained from aggregated weighted Z statistics (Liu et al, 2019). P-values for DLFPC-eQTL meta-analysis were obtained using conventional inverse-variance-weighted meta-analysis as implemented in the SMR software package. Color of each dot presents the R2 for LD at the locus (Red = 0.8–1.0; Orange 0.6–0.79; Green 0.4–0.59; Blue 0.2–0.39 and dark blue <2.0). B The co-localized SNPs were found to be overlapping with the chromatin interaction region that loops back to the promoter of the MAPT gene. C In independent transcriptomic data from the human brain (N = 92), mRNA expression of MAPT was found to be associated with the alcohol consumption. The analysis was performed using DeSeq2 program and P-value for association resulted from the Wald test. The shaded area around trend-line depicts the 95% confidence level intervals plotted using “geom_smooth(method = “lm”)” from ggplot2.

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