Table 1 SMR analysis results with summary statistics of AUD GWAS meta-analysis.

From: Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

Chr

BP

Gene

Adult brain

Fetal brain

eQTL p value

mQTL p value

eQTL p value

mQTL p value

11

46399942

SPI1N

x

x

x

1.91E−04

46664086

MTCH2

1.89E-05

x

x

x

46843734

NUP160

3.88E-04

x

x

x

3

48395716

GPX1

4.93E-05

x

x

x

48459884

AMT

2.07E-04

x

4.39E−04

4.47E−01

17

43361331

MAP3K14N

x

x

x

2.99E−05

  1. The reported genes from the integration analyses survived four different P value thresholds to be nominated as potential causal candidate genes (GWAS P  =0.05; FDRSMR-P < =0.2). SMR P-values for the co-localized SNPs are obtained using the Wald test. The superscript N in front of gene indicates the potential candidate causal gene prioritized using current multi-omic analysis.
  2. Chr chromosome, BP start position of the gene, Gene candidate causal gene, p value SMR P values for integration of AUD summary statistics with respective eQTL/mQTL annotation from adult or fetal brain). x denotes the missing values either due to non-significant results or sub-threshold expression or methylation values in the respective tissue.
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