Fig. 6: Model of Yta7 chromatin segregase mechanism and regulation.
From: A CDK-regulated chromatin segregase promoting chromosome replication
Recruitment of Yta7 to chromatin is facilitated by H3 acetylation. In the S phase, Yta7 is phosphorylated by CDK, which stimulates its ATPase activity. Hydrolysis of ATP is then necessary to segregate histones from DNA. This cell cycle-regulated alleviation of the chromatin barrier promotes S phase chromosome replication to preserve genome stability. See text for details.
