Fig. 3: Circulating parameters in newborns after the cold stimulus.
From: BMP8 and activated brown adipose tissue in human newborns
a–f Circulating levels of glucose, TG, T4, T3, FGF21, and BMP8B in newborns at postnatal days of life 1 or 2, under control or cold exposed conditions. Number of newborns/group (order of groups): a 24, 26, 24, and 26, b 24, 22, 19, and 23, c 24, 26, 22, and 24, d 24, 26, 24, and 25, e 13, 18, 14, and 19, f 18, 15, 16, and 15. Box plots indicate median (middle line), 25th, 75th percentile (box), and 10–90th percentiles (whiskers; minima and maxima, respectively). Glucose cold exposed day 1 vs. glucose cold exposed day 2 P = 0.007; Glucose control day 2 vs. glucose cold exposed day 2 P = 0.039; TG control day 1 vs. TG control day 2, P < 0.0001; TG cold exposed day 1 vs. TG cold exposed day 2, P < 0.0001; TG control day 2 vs. TG cold exposed day 2 P = 0.047; FGF21 control day 1 vs. FGF21 cold exposed day 1 P = 0.025; FGF21 control day 1 vs. FGF21 control day 2 P = 0.05; BMP8B control day 1 vs. BMP8B cold exposed day 1 P = 0.023; BMP8B control day 1 vs. BMP8B control day 2 P = 0.001. Statistical significance was determined by two-sided linear mixed models followed by contrast of marginal means differences, with P values adjusted by Holm’s method. Results are shown for interaction term (Treatment:Day). *P < 0.05 or P = 0.05 (for FGF21) **P < 0.01, ***P < 0.001. Statistical parameters for panels a–f are summarized in Supplementary Table 3. Source data are provided as a Source data file.
