Fig. 7: Cold exposure improves a subsequent thermogenic response in newborns.
From: BMP8 and activated brown adipose tissue in human newborns
a Body temperature changes on day 1 and day 2 in cold exposed newborns. A number of newborns/group: 25. Data represent mean ± SEM. t = 3 day 1 vs. t = 3 day 2 P = 0.031; t = 7 day 1 vs. t = 7 day 2 P = 0.0061. b Violin plot showing the individual body temperature changes between minute 3 and minute 7 at day 1 and day 2 in cold exposed newborns. A number of newborns/group: 25. Violin plots indicate median (middle line), 25th, 75th percentile (box) and Q1 − 1.5× IQR (interquartile range) and Q3 + 1.5× IQR (whiskers; minima and maxima, respectively). P = 0.03. c Violin plot showing the individual body temperature changes between minute 0 and minute 7 at day 1 and day 2 in cold exposed newborns. A number of newborns/group: 25. Violin plots indicate median (middle line), 25th, 75th percentile (box) and Q1 − 1.5× IQR (interquartile range) and Q3 + 1.5× IQR (whiskers; minima and maxima, respectively). P = 0.016. Statistical significance for panels a–c was determined by two-sided linear mixed models followed by contrast of marginal means differences, with P values adjusted by Holm’s method. *P < 0.05, **P < 0.01. d, i Correlation between BAT temperature change and circulating factors in cold exposed newborns at postnatal day 2. Number of newborns/group: d 25, e 22, f 23, g 24, h 18, i 15. Association analysis was performed by two-sided Pearson’s test or Spearman’s test; regression line with 95% confidence interval was added when correlation was significant. Source data are provided as a Source data file.
