Fig. 2: Effect of ERDRP-0519 on manifestation of clinical signs in MeV-infected squirrel monkeys.
From: Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
a Schematic illustration of the experimental design. Each group was treated twice daily (b.i.d.) over a 14-day period, illustrated by colored lines. Prophylactic treatment started 12 h prior to infection (green); therapeutic treatment started on day 3 post-infection (therapeutic (d3), red), or on day 7 post-infection (therapeutic (d7), blue). Dpi, days post-infection. b Clinical scores of infected animals. Each row represents one animal of the respective group and color intensity indicates severity of clinical signs categorized as no signs (white) or individual spots, multiple spots, mild rash, and general rash (light to dark graduation). Gray, crossed areas represent deceased animal. c Representative photographs of the abdomen of a prophylactically treated animal (left) and an untreated animal (right), taken 13 days post-infection.
