Fig. 2: Serum autoantibodies in COVID-19 patients recognize antigens targeted in rare connective tissue diseases, and antigens associated with pathogenicity.
From: New-onset IgG autoantibodies in hospitalized patients with COVID-19
Boxplots of twelve antigens corresponding to Fig. 1. a Antigens associated with autoimmune myositis and myocarditis (MDA5, troponin 1, MYH6 (alpha-myosin), PL-7, Jo-1, and Mi-2). b RNA-containing antigens associated with systemic sclerosis (RPP25 Th/To, Fibrillarin, and U11/U12). c Antigens that may be pathogenic (C1q and β2GP1) and associated with vasculitis (BPI). MFI data in a–c are represented as boxplots where the middle line is the median, the lower and upper hinges correspond to the first and third quartiles, the upper whisker extends from the hinge to the largest value, and the lower whisker extends from the hinge to the smallest value. Individual MFI values are displayed as dots. MFI is shown on the y-axis. Subjects are shown on the x-axis (n = 51 unpaired UPenn and Marburg COVID-19 patients and n = 31 HC). Source data are provided as a Source Data file.
