Fig. 4: Effects on diagnostic delay in different diseases.
From: Insights into the expanding phenotypic spectrum of inherited disorders of biogenic amines
a Diagnostic delay in disorders of biogenic amine metabolism and BH deficiencies. White spot: median, black bars: interquartile range (25% and 75%), n: number reported. b Effect of date of birth on diagnostic delay; bold line: significant, two-sided WMW-test, p < 0.05, cDiagnostic delay in arGTPCHD, PTPSD and DHPRD in patients without any or normal newborn screening (NBS) results (n = 24) vs. patients with hyperphenylalaninemia (HPA) on NBS (n = 47); two-sided t-test, p = 0.006. dDiagnostic delay in arGTPCHD regarding HPA on NBS (n = 5) vs. normal NBS (n = 6); two-sided t-test, p = 0.11. eDiagnostic delay in DHPRD in patients having HPA on NBS diagnosed directly after NBS (n = 6) vs. via selective screening (n = 14); two-sided t-test, p = 0.08. Diamond: arithmetic mean, bold line: median, boxes present interquartile range (25% and 75%).
