Fig. 2: Contribution of enzalutamide treatment-mediated chromatin reprogramming to transcription factor DNA motif footprint. | Nature Communications

Fig. 2: Contribution of enzalutamide treatment-mediated chromatin reprogramming to transcription factor DNA motif footprint.

From: Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Fig. 2

a, b Normalized average formaldehyde-assisted isolation of regulatory element (FAIRE)-seq read distribution in androgen-deprived conditions within a 2-kb interval around a MYC-binding sites and b AR-binding sites in LNCaP cells. Sample comparisons of enrichment values at the middle of the distribution are indicated using colored dots within the plots and the two-sided t-test p-value is shown. c Prostate cancer-associated transcription factor (TF) motif enrichment in open differentially accessible regions (DARs) for each single-cell ATAC-seq sample. Enrichments with a Benjamini–Hochberg method-adjusted hypergeometric test p-value < 0.05 are shown in colors, while nonsignificant (ns) enrichments are shown in white. The barplots above the matrices indicate the number of open DARs found for each cluster in each sample. d TF motif enrichments in open DARs observed comparing the indicated conditions. Enrichments with a Benjamini–Hochberg method-adjusted hypergeometric test p-value < 0.05 are shown in colors, while nonsignificant (ns) enrichments are shown in white. See also Supplementary Fig. 2.

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