Fig. 1: Association between hepatitis C virus (HCV) amino acids and sofosbuvir-based treatment outcome. | Nature Communications

Fig. 1: Association between hepatitis C virus (HCV) amino acids and sofosbuvir-based treatment outcome.

From: Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

Fig. 1

A Manhattan plot of association tests between HCV amino acids and treatment outcome. At each viral site only the p-value for the most associated amino acid is plotted. The dashed line indicates 15% false discovery rate. For the three sites significantly associated with outcome and the most associated site in the non-structural 5B (NS5B) protein, the amino acid associated with the lowest cure rate at the site and its position within its respective protein is indicated. B Schematic of HCV polyprotein.

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