Fig. 7: TRAPPC4 maintains the expression of PD-L1 by regulating its intracellular trafficking.
From: TRAPPC4 regulates the intracellular trafficking of PD-L1 and antitumor immunity
In the tumor cell cytoplasm, TRAPPC4 acts as a scaffold for endocytosed PD-L1 and RAB11, thus facilitating the RAB11-mediated recycling of PD-L1 and restoring the distribution of PD-L1 on the cell surface. Disruption of TRAPPC4 in CRC cells leads to a redistribution of endocytosed PD-L1 to lysosomes and its degradation, resulting in enhanced T-cell-mediated cytotoxicity toward colorectal tumor cells.
