Fig. 5: Structure of LRRC8A in complex with the inhibitory sybodies Sb2 and Sb3.
From: Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
a Surface representation of the LRRC8A/Sb2 complex structure. b Structure of the dimer of interacting domains at the tight interface with bound sybody Sb2. c Surface representation of the LRRC8A/Sb3 complex structure. d Structure of the dimer of interacting domains at the tight interface with bound sybody Sb3. b, d Left (l) and right (r) positions are indicated. e Ribbon representation of a single LRR domain with bound sybodies Sb2 and Sb3. Repeats contacted by both sybodies are labeled. f View on the interaction interface of a homology model of Sb2 based on the Sb3 structure, g the LRRC8A domain and, h Sb3. The protein is shown as Cα trace with the sidechains of interacting residues displayed as sticks.
