Fig. 7: Structure of LRRC8A in complex with the potentiating sybodies Sb4 and Sb5.
From: Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
a Surface representation of the LRRC8A/Sb4 complex structure. b Structure of the dimer of interacting domains at the loose interface with bound Sb4. c Surface representation of the LRRC8A/Sb5 complex structure. d Structure of the dimer of interacting domains at the loose interface with bound Sb5. b, d Left (l) and right (r) positions are indicated. e Ribbon representation of a single LRR domain with bound sybodies Sb4 and Sb5. Repeats contacted by one of the two sybodies are labeled. a–e Due to the low resolution of cryo-EM densities of binders in the respective maps, Sb4 and Sb5 structures are based on homology models of both sybodies.
