Fig. 10: Schematic illustration of the role of fat-derived NT-3 and its receptor TRKC at sympathetic ganglia in the regulation of SNS innervation in adipose tissue. | Nature Communications

Fig. 10: Schematic illustration of the role of fat-derived NT-3 and its receptor TRKC at sympathetic ganglia in the regulation of SNS innervation in adipose tissue.

From: Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue

Fig. 10

Briefly, the neurotrophic factor NT-3 secreted from adipose tissue acts through its receptor TRKC in sympathetic ganglia to promote SNS innervation in brown and white adipose tissues, which in turn stimulates BAT thermogenesis and WAT beiging, leading to increased energy expenditure and protection from diet-induced obesity.

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