Fig. 2: Mettl3 deletion in NK cells fails to control tumor development.
From: METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
a Imaging of lungs (left) and tumor nodules in lungs (right) from WT (n = 6) or cKO (n = 4) mice 16 days after intravenous injection of 5 × 105 B16/F10 cells. b Imaging of livers (left), and tumor nodules in livers (right) from WT (n = 6) or cKO (n = 4) mice 16 days after intravenous injection of 5 × 105 B16/F10 cells. c Representative hematoxylin and eosin (H&E) staining images of the liver (top) and lung samples (bottom) from WT mice or cKO mice after intravenous injection of 2 × 105 B16/F10 cells. Scale bars represent 1 mm. d Survival of WT mice (n = 7) and cKO mice (n = 5) after intrasplenic injection of 2 × 105 MC38 cells. e Survival of WT mice (n = 8) and cKO mice (n = 12) after intrasplenic injection of 2 × 105 B16/F10 cells. f Survival of WT mice (n = 9) and cKO mice (n = 7) after intravenous injection of 5 × 105 MC38 cells. g Survival of WT mice (n = 5) and cKO mice (n = 5) after intravenous injection of 2.5 × 105 B16/F10 cells. h WT mice or cKO mice were co-transferred with 5 × 106 CFSE-labeled RMA cells and 1.5 × 107 CTV labeled RMA-S cells, and splenocytes were harvested 16 h later. i Representative plots (left) showing expression of CTV and CFSE in the spleen, and a statistical graph showing the ratio of RMA-S cells: RMA cells (n = 7) or cKO (n = 5) mice in (i). Each symbol represents an individual mouse (a, b, d, e, f, g, i). Data are the mean ± SEM (unpaired two-tailed t test (a, b, i) or two-tailed log-rank (Mantel–Cox) test (d–g)). Source data are provided as a Source Data file. Data represent at least two independent experiments (a–d, g-i) or are pooled from two independent experiments (e, f).
