Fig. 3: Differential gene landscapes and pathway analysis at different stages of SFTSV infection. | Nature Communications

Fig. 3: Differential gene landscapes and pathway analysis at different stages of SFTSV infection.

From: A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome

Fig. 3

a, b Three patients with covering different stages of infection. a Clustered heat map showing significant differential expression of 955 genes identified by RNA-seq at different stages of SFTSV infection. Stage: S1 (Fever stage); S2 (Deterioration/Organ failure), S2-1 represents the early stage of S2 and S2-2 represents the later stage of S2; S3 (Improving); S4 (Convalescence). b Box plots showing the 955 genes CPM levels of three patients at different stages. The left and right dotted lines show downregulation (the SFTSV-positive sample was downregulated compared with the SFTSV-negative sample, n = 468 genes) and upregulation (the SFTSV-positive sample was upregulated compared with the SFTSV-negative sample, n = 487 genes) of gene expression after SFTSV infection, respectively. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; points, outliers. c GO analysis of the human transcripts containing differential expression genes upon SFTSV infection using DAVID bioinformatics database (the p values are provided by DAVID online tool).

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