Fig. 3: Overview of complex chromosomal rearrangements (CCRs).
From: Parity associates with chromosomal damage in uterine leiomyomas
a Summary of CCR statuses for all 1935 tumors (purple), stratified by patient’s parity. Similarly, CCR statuses among MED12 mutated tumors (salmon) and among WT tumors (turquoise). b Association between whole chromosome loss and parity. c, Breakpoint number in tumors with CCR, stratified by nulliparous (n = 45 tumors) and parous patients (n = 134 tumors). Orange dots depict MED12 mutated tumors, turquoise WT tumors. Of note, all ULs with a high breakpoint number are from parous patients’ WT tumors. The mean number of breakpoints in CCR–nulliparous tumors is 13.0 (95% CI: 10.93–15.79) and in CCR–parous tumors 18.17 (14.74–22.14). d, An average breakpoint number, total length of loss regions, total length of gain regions and the combined length of loss and gain regions are presented for MED12 tumors with CCR (n = 52) from parous (n = 36) and nulliparous patients (n = 16). 95% bootstrap confidence intervals are presented for the mean. e An average breakpoint number, total length of loss regions, total length of gain regions and the combined length of loss and gain regions are presented for WT CCR tumors (n = 127) from parous (n = 98) and nulliparous patients (n = 29). 95% bootstrap confidence intervals are presented for the mean. Source data are provided.
