Fig. 2: Synthetic scope of alcoholsa. | Nature Communications

Fig. 2: Synthetic scope of alcoholsa.

From: Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols

Fig. 2

aReaction conditions: 1 (1.0 equiv.), 2a (16.0 equiv.), 0.5 mol % LPTS, THF, 25 oC, 12 h. b20.0 mol % LPTS, 48 h. c2.0 mol % LPTS, 24 h. d5.0 mol % LPTS, 48 h. Yields of isolated products are given. ePurity of 3 is provided, as determined by 1H NMR. fLarge scale synthesis: 50 mmol 1, isolated yields by distillation.

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