Fig. 4: Ketal-linked prodrugs.

a synthesis of PEG-K-DEX; b structures of LA-K-CAPME, LA-K-BUF, and HSA-K-DEX; c synthesis of PK5F; d structures of PTX-7-K-EG3, PK3F, and PK5E.
a synthesis of PEG-K-DEX; b structures of LA-K-CAPME, LA-K-BUF, and HSA-K-DEX; c synthesis of PK5F; d structures of PTX-7-K-EG3, PK3F, and PK5E.