Fig. 7: In vivo and ex vivo PDAC matrisome analysis.
From: Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
a Scatter plot showing the total abundance and number of proteins of each matrisome category for each primary tumour analysed. b Principal component analysis of the core matrisome datasets from patients 12556, 12559, 12560, 12707 and 12975. c Scatter plot showing the correlation between the number of proteins of the primary core matrisomes and those of their corresponding PDX, PA-ECM and organoid models. The PDX murine baseline indicates the number of murine ECM proteins predicted to reside at the site of PDX implantation. d Percentage of matrisome peptides detected in the PDX and organoid samples which are of human, mouse or common origin. Common peptides are identical in both species. e Colour-coded correlation between the core matrisome protein abundances in primary tumours and their corresponding PDX, PA-ECM and organoid models. R is the correlation coefficient.
