Fig. 4: smEVs released from cilia mutant cells contain differentially loaded miRNAs involved in Wnt signalling.
From: Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
a, b Volcano blots of miRNAs isolated from three independent smEV prepartions from Bbs4−/− (a) and Bbs6−/− (b) cells compared to control. Upregulated miRNAs are depicted by red dots, downregulated by blue dots. c, d Heatmaps of all differentially loaded miRNAs with a log2 fold change ≥2 or ≤ −2 and adjusted P value <0.1 compared to control. miRNAs with target genes related to the Wnt signalling pathway are marked in purple. Source data are provided as a Supplementary data file.
