Table 2 Gene ontology enrichment analysis (getgo.russelllab.org) of proteins highly enriched in ciliary mutant smEVs.
From: Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
EV sample | Term | Signalling pathway | Fisher-C-PV |
|---|---|---|---|
Bbs4−/− smEVs | GO:0090090 | Negative regulation of canonical Wnt signalling pathway | 6.005 × 10−07 |
GO:0090263 | Positive regulation of canonical Wnt signalling pathway | 1.099 × 10−06 | |
GO:0048011 | Neurotrophin TRK receptor signalling pathway | 0.002384 | |
GO:0048013 | Ephrin receptor signalling pathway | 0.00912 | |
GO:0007179 | Transforming growth factor-beta receptor signalling pathway | 0.01076 | |
GO:0007173 | Epidermal growth factor receptor signalling pathway | 0.02680 | |
Bbs6−/− smEVs | GO:0090263 | Positive regulation of canonical Wnt signalling pathway | 2.093 × 10−05 |
GO:0090090 | Negative regulation of canonical Wnt signalling pathway | 7.957 × 10−04 | |
GO:0048013 | Ephrin receptor signalling pathway | 0.00113 | |
GO:0097193 | Intrinsic apoptotic signalling pathway | 0.00165 | |
GO:0007229 | Integrin-mediated signalling pathway | 0.00232 | |
GO:0048011 | Neurotrophin TRK receptor signalling pathway | 0.00881 | |
GO:0048010 | Vascular endothelial growth factor receptor signalling pathway | 0.02178 | |
GO:0030512 | Negative regulation of transforming growth factor-beta receptor signalling pathway | 0.04295 | |
GO:0007173 | Epidermal growth factor receptor signalling pathway | 0.04805 |
