Table 4 Wnt-related miRNAs and their predicted target genes.
From: Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles
Possible Wnt-related target genes | Expression | |||
|---|---|---|---|---|
miRNA | TargetScanMouse | miRDB | Bbs4−/− smEVs | Bbs6−/− smEVs |
mmu-miR-34b | Ctnna2, Ctnna3, Ctnnd1, Dkk2, Fzd1, Fzd2, Fzd5, Sfrp1, Sox17, Wisp1, Wnt2, Wnt2b, Wnt3, Wnt5a, Wnt9b, Wnt10a | Ctnnb1, Ctnnd2, Fzd, Sfrp5, Wnt5a | ↑ | ↑ |
mmu-miR-34c | Ctnna3, Fzd3, Fzd5, Fzd8, Wif1, Wls, Wisp1, Wnt2, Wnt2b, Wnt4, Wnt7b, Wnt9a | Ctnnd2, Lef1, Wif1, Sfrp5 | ↑ | ↑ |
mmu-miR-135b | Ctnna1, Ctnna3, Dkk3, Dvl3, Fzd4, Wisp3, Wnt1, Wnt7b, Wnt9a | Wnt3 | ↑ | ↑ |
mmu-miR-141 | Apc, Ctnna3, Ctnnal1, Ctnnd1, Ctnnd2, Dkk3, Dvl2, Wnt2, Wnt3a, Wnt4, Wnt5a, Wnt5b, Wnt8b, Wnt9b | Apc2, Ctnnb1, Ctnnd2, Dkk3, Wnt5b, Wnt9b | ↑ | ↑ |
mmu-miR-200c | Ctnna3, Dkk2, Dvl3, Fzd3, Fzd6, Fzd9, Sfrp1, Wnt2b, Wnt4, Wnt11 | Apc, Ctnnd2, Dkk2 | ↑ | ↑ |
mmu-miR-101a | Apc, Ctnna2, Ctnna3, Ctnnal1, Ctnnbip1, Ctnnd1, Dkk3, Dvl3, Fzd4, Fzd6, Fzd9, Wisp3, Wnt2b, Wnt8a | Apc, Fzd4, Fzd6, Wnt2b | ↓ | / |
mmu-miR-101c | Apc, Ctnna2, Ctnna3, Ctnnal1, Ctnnd1, Dkk4, Dvl1, Fzd3, Fzd4, Fzd5, Fzd8, Fzd9, Wisp3 | Dkk4, Fzd4 | ↓ | / |
mmu-miR-122 | Ctnnb1, Wisp1, Wnt4 | Apc, Ctnna1, Ctnnb1, Ctnnd1, Dvl1, Sfrp1, Wnt9a | ↓ | / |
mmu-miR-181d | Apc, Ctnnd1, Fzd1, Fzd9, Wnt5a, Wnt8a | Dkk1, Wls | ↓ | / |
mmu-miR-203 | Apc, Ctnna2, Ctnna3, Ctnnal1, Ctnnd1, Ctnnd2, Dvl2, Fzd4, Fzd5, Fzd7, Fzd8, Wls, Wnt2, Wnt4, Wnt5a, Wnt7a, Wnt7b, Wnt11 | Lef1, Wnt7a | ↓ | / |
