Fig. 1: Schematic illustration of HGF-relevant preparation and therapeutic strategy. | Nature Communications

Fig. 1: Schematic illustration of HGF-relevant preparation and therapeutic strategy.

From: A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

Fig. 1

a The exosome inhibitor (GW4869) with ferroptosis inducer (iron ion) were unified into a HA (hyaluronic acid) based nanoplatform (HGF NPs). b With intravenous administration released GW4869 from HGF NPs significantly decreased tumor-derived exosome generation, resulting in activated anti-tumor immune response and a robust memory response against tumor cells. Furthermore, re-activated T cells released a high level of IFN-γ (interferon-γ) cytokine to downregulate the expression of SLC7A11 and SLC3A2, both of which are responsible for the synthesis of intracellular anti-oxidant cystine, enhancing the ferroptosis induced by an enriched iron source from HGF NPs.

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