Fig. 4: T-DM1 and RAB GTPase correlations in the I-SPY2 cohort.

A Number of patients, hormone receptor (HR) status, and pathological complete responses (pCR) in the T-DM1 + pertuzumab and trastuzumab-paclitaxel arm of the I-SPY2 study. B Association plot summarizing qualifying biomarker analyses of RAB4A, RAB5A, and RAB11A expression levels as specific predictors of pCR to indicated treatment. Results are organized by the logistic model/data used along the rows, and the biomarker evaluated along the columns. Circle sizes are proportional to the significance (−log10 (LR test p)); and circle color reflects the magnitude of coefficient (red: positive, blue: negative) from each corresponding logistic model. White background indicates p < 0.05, and the odds ratio associated with 1 standard deviation increase in expression were also shown (in white) inside the circle. The 95% confidence intervals for the coefficients are found in Supplementary Table 1. Source data are provided as a Source Data file.