Table 1 Cellular sensitivity of trastuzumab and T-DM1.

From: RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer

Cell line

Trastuzumab sensitivity

T-DM1 sensitivity (IC50 (µg/ml))

SK-BR-3

+++

+++ (0.0058)

SKOV-3

−

+ (1.2)

AU-565

+++

+++ (0.0046)

HCC1954

+

+++ (0.0065)

MDA-MB-435

+

++ (0.12)

  1. The table shows trastuzumab sensitivity (not sensitive (−), low sensitivity (+), high sensitivity (+++)), and T-DM1 sensitivity (IC50 average of three experiments) in the indicated cell lines. Graphic presentations of the viability data are found in Fig. 1. Source data provided.
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