Fig. 3: Associations between HER family mRNA-, protein- and phosphoprotein-based pathway activation and pCR. | Nature Communications

Fig. 3: Associations between HER family mRNA-, protein- and phosphoprotein-based pathway activation and pCR.

From: Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial

Fig. 3

A Mosaic plot showing the proportion of patients who had pCR (purple) or did not have pCR (yellow) as a function of HER2 IHC level (1+, 2+, 3+; left to right), in the TDM1/P (top), THP (center), and control (bottom) rows. Barplots in B show these data by arm. Pink: IHC 1+; Light Blue: IHC 2+; Blue: IHC 3+. Panels C, D show response-association boxplots of a HER2 mRNA signature overall (C; n = 127) and by arm (D; n = 52 (TDM1/P), 44 (THP), and 31 (Ctr)) Yellow box is non-pCR, light blue box is pCR. Color of data points correspond to IHC level as in panel B. Panels E, F show response-association boxplots of HER2 total protein overall (E; n = 117) and by arm (F; n = 49 (TDM1/P), 43 (THP), and 25 (Ctr)). Yellow box is non-pCR, light blue box is pCR. Color of data points correspond to IHC level as in panel B. G Two-way scatter plot of phosphorylated HER2 (Y1248) (y-axis) and phosphorylated EGFR (Y1173) (x-axis) relative intensity (RI) values generated from the LCM-RPPA data in the pretreatment biopsy samples are shown along with pCR YES (green) and pCR NO (red) designations. For box plots, center line is group median; upper and lower limits of the box correspond to the 1st and 3rd quartile with whiskers extending to 1.5 times the interquartile range from top/bottom of the box.

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