Fig. 4: Associations between HR/luminal and proliferation biomarkers and pCR.

A, B shows HR expression (ESR1 and PGR averaged) response-association boxplots in all patients (A; n = 127) and by arm (B; n = 52 (TDM1/P), 44 (THP), and 31 (Ctr)). For all box plots, yellow box indicates non-pCR, light blue indicates pCR. C Bar plot showing the prevalence of PAM50 subtypes (LumA: light blue; LumB: dark blue; HER2:red; Basal: magenta) in patients achieving pCR compared to non-responders in the population as a whole (left pair of bars, n=126) and by arm (right pairs, n = 51 (TDM1/P), 44 (THP), and 31 (Ctr) n = 51 (TDM1/P), 44 (THP), and 31 (Ctr)). D–F show response-association boxplots of proliferation biomarkers on the mRNA (D; n = 83), protein (E; n = 78) and phospho-protein (F; n = 78) levels in the HR⁺/HER2⁺ subset by arm. *Association is significant (LR p < 0.05) only for TDM1/P, broken rectangle. For box plots, center line is group median; upper and lower limits of the box correspond to the 1st and 3rd quartile with whiskers extending to 1.5 times the interquartile range from top/bottom of the box.