Fig. 7: Telomere–LINC complex association is required for chromosome end alignment over a substantial range. | Nature Communications

Fig. 7: Telomere–LINC complex association is required for chromosome end alignment over a substantial range.

From: Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment

Fig. 7

a Genome-wide Hi-C interaction heatmaps binned at 1 Mb resolution for Sun1W151R/W151R mutant zygotene spermatocytes. b Chr1 interaction heatmaps binned at 1 Mb resolution for Sun1W151R/W151R mutant zygotene spermatocytes. c P(s) curve of Sun1W151R/W151R mutant zygotene spermatocytes exhibits a similar shape to wild-type zygotene spermatocytes. d Interaction heatmaps at 500 kb resolution showing trans observed interaction frequencies among chromosomes 3, 5, 9, and 17. Different chromosomes only exhibit association at the very tips of chromosomes. e Averaged trans observed/expected heatmaps of 171 pairwise combinations of autosomes in Sun1W151R/W151R mutant zygotene spermatocytes. f Plots compare signals along the diagonals of the averaged trans heatmaps for wild-type and Sun1W151R/W151R mutant zygotene spermatocytes. The inter-chromosomal alignment profile abruptly drops off at the telomere-distal end. g Cartoons illustrate the effects of telomere association with the force-transmitting LINC complex on the alignment of chromosome ends.

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