Fig. 2: Expression of PDAC subtype signatures. | Nature Communications

Fig. 2: Expression of PDAC subtype signatures.

From: Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

Fig. 2

a Heatmap showing the expression of Moffitt subtype signature genes across individual clusters from all patients. b Distribution of Moffitt subtype scores across PDAC organoid cells, shown for two homogeneous (top) and two heterogeneous (bottom) samples. Blue indicates classical subtype scores, red basal-like (“Methods”). c Top: eight distinct clusters of cells were identified in p100. Bottom: expression of characteristic genes for the basal-like (top) and classical (bottom) subtype across clusters, showing significantly higher expression of classical genes and lower expression of basal-like genes in cluster 8 compared to all others. d Proportion of homogeneous and heterogeneous organoids that were classified as grade 2, 3, or 4 by histopathological assessment of the original tumor.

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