Fig. 1: Serum IL-31 levels correlated with fibrosis and Th2 polarization in SSc.
From: Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis
a Serum IL-31 levels were determined in dcSSc patients (n = 55), lcSSc patients (n = 19), and healthy controls (n = 14) by a specific ELISA kit. The horizontal lines represent the mean values. The broken line represents the cut-off value (mean + 2 SD of the healthy controls). **p < 0.01 and ***p < 0.001 vs. healthy controls. Significance was evaluated by two-tailed Mann–Whitney U test. Exact p values = 0.00002 (SSc vs. Ctrl), 0.000008 (dcSSc vs. Ctrl), 0.008 (lcSSc vs. Ctrl). Ctrl; healthy controls. b Correlations between serum IL-31 levels and the following parameters were analyzed in SSc patients (n = 74): MRSS, %VC, %DLco, serum IL-4 levels, serum IL-6 levels, and serum IL-13 levels. Correlations were assessed by Spearman’s rank correlation test. Exact p values = 0.000000005 (MRSS); 0.005 (%VC); 0.033 (%DLco); 0.012 (IL-4); 0.00003 (IL-6); 0.026 (IL-13). Source data are provided as a Source Data file.
