Fig. 5: Afucosylated PfEMP1-specific IgG induces NK-cell-mediated ADCC. | Nature Communications

Fig. 5: Afucosylated PfEMP1-specific IgG induces NK-cell-mediated ADCC.

From: Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Fig. 5

a VAR2CSA-specific IgG fucosylation levels of samples with low (open symbols) and high fucose (filled symbols) levels. b Comparison of VAR2CSA-specific IgG levels and c CD107a expression between highly fucosylated (filled symbols) and afucosylated anti-VAR2CSA IgG1 (open symbols) samples, respectively. Mean from three independent experiments and P values from two-sided Mann–Whitney tests are shown. d VAR2CSA-specific, human monoclonal antibody PAM1.4 as either fucosylated or afucosylated IgG1 was titrated in the same assay and VAR2CSA-binding or e degranulation activity (CD107a expression) on NK92-CD16a cells was measured. IgG: non-immune human IgG. Data represent mean values ± SD from three independent experiments.

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