Fig. 4: Tissue-specific strong enhancers (EnhA) and their potential functions in 14 tissues. | Nature Communications

Fig. 4: Tissue-specific strong enhancers (EnhA) and their potential functions in 14 tissues.

From: Pig genome functional annotation enhances the biological interpretation of complex traits and human disease

Fig. 4

a The number and enrichment distribution of 17 modules of TSR (strong enhancers (EnhA)) in tissues. TSR tissue-specific regulatory elements. The top colors represent 17 modules of strong enhancers (column) referred to by the legend on the right. The side colors represent 14 tissues (row), also referred to by the legend on the right. b Functional enrichment of proximal genes for each module based on gene ontology (GO) biological processes. The columns represent 17 modules of strong enhancers. The rows represent GO terms in each module. All GO terms are presented in Supplementary Data 5. Notes within the heatmap summarize functions of nearby GO terms (up-noted from jejunum to spleen, down-noted for lung, muscle, and adipose). c The average expression (TPM) of EnhAs’ putative target genes in each module. The columns represent the genes in each module, the rows represent each tissue. d The enrichment of transcription factor motifs in each module. The columns represent 17 modules of EnhAs. The rows represent motifs. All enriched motifs are presented in Supplementary Fig. 10a. The P values were generated by HOMER. e Enrichment for human phenotypes in each module, based on proximal genes. The columns represent 17 modules of EnhAs. The rows represent phenotypes. The enrichment of all phenotypes is presented in Supplementary Data 7. Notes within the heatmap summarize nearby enriched phenotypes, with the color of the text indicating the corresponding tissue.

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