Fig. 3: Closeup view of the TMD and ECD. | Nature Communications

Fig. 3: Closeup view of the TMD and ECD.

From: Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease

Fig. 3

a–c Surface and ribbon representations of the transmembrane domains (TMD). EM densities of the lipids are indicated with an arrow. a EM density resembling a lipid is located in between TM1/2/11. b Orthogonal view. c Most probable orientation of the lipid (black) between TMD1 and TMD2. N- and C- halves of ABCA4 are colored as dark green and light green, respectively. d–f Surface and ribbon representations of the exocytoplasmic domains, showing (d) the tunnel that is accessible from the lumen side. e EM density was also found on the opposite side of the exocytoplasmic domain (ECD), indicated as purple mesh. f Orthogonal view of ECD showing the EM densities (arrow).

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