Fig. 6: A model for LD formation by the Sei1-Ldb16 complex.
From: Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
Sequential TAG interactions mediate LD assembly by the Sei1-Ldb16 complex. In the ER bilayer, TAG molecules (blue) concentrate in proximity of Seipin oligomers (orange) via weak interaction with Sei1 TMs. TAG molecules within the ring interact strongly with Ldb16 (green) hydroxyl-containing residues, facilitating TAG coalescence and lens formation (see text for details).
