Fig. 4: Multi-tissue methylome divergence in Lake Malawi cichlids is associated with early development/embryogenesis.
From: Mapping epigenetic divergence in the massive radiation of Lake Malawi cichlid fishes
a Distinct species-specific methylome patterns in Lake Malawi cichlids can be found in liver or muscle tissues, or in both tissues (‘multi-tissue’). b Histograms showing the total counts of ‘species’ DMRs that are either liver-, muscle-specific or present in both (multi). Only ‘species’ DMRs showing distinct DNA methylation patterns in one species are shown. c GO enrichment plots for each DMR class. Only GO terms with Benjamini−Hochberg FDR-corrected p-values < 0.05 are shown. d−f Examples of ‘species’ multi-tissue DMRs in genes related to embryonic and developmental processes. Namely, in the genes coding for visual system homeobox 2 vsx2 (LOC101486458), growth-associated protein 43 gap43 (LOC101472990) and teneurin transmembrane protein 2 tenm2 (LOC101470261). Liver and muscle methylome profiles shown in green and purple, respectively (averaged mCG/CG levels [%] in 50 bp bins for ≥2 samples per tissue per species; scale indicated below each graph).
