Fig. 2: Reaction optimization.
From: Ni-catalyzed hydroalkylation of olefins with N-sulfonyl amines
a Evaluation of base. b Evaluation of boron reagent. c Evaluation of ligand. d Standard reaction conditions. e Gram-scale reaction. Reaction conditions: 1a (0.2 mmol), 2a (0.4 mmol), Ni(cod)2 (10 mol%), ligand (20 mol%), PhB(OH)2 (25 mol%), base (25 mol%), toluene (0.3 mL), N2, 120 °C; yields were determined by 1H NMR spectroscopy. aWithout PhB(OH)2. bLigand (10 mol%). B boron, Ac acetyl, Bu butyl, Me methyl, TMS trimethylsilyl, KHMDS potassium bis(trimethylsilyl)amide, Ph phenyl, Pr propyl.
