Fig. 8: Increasing dmPFC-DMS projection neuron activity via ketamine or optogenetic stimulation rescues compulsive grooming behavior. | Nature Communications

Fig. 8: Increasing dmPFC-DMS projection neuron activity via ketamine or optogenetic stimulation rescues compulsive grooming behavior.

From: Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice

Fig. 8

Graphical summary of the paper showing: a Ketamine produces a decrease in grooming behavior that is correlated with an increase in dmPFC-DMS projection neuron activity in SAPAP3 KO mice. This rescue of compulsive grooming behavior is causally reproduced by selectively stimulating dmPFC-DMS projection neurons. b Ketamine has no effect on grooming behavior or dmPFC-DMS circuit activity in WT mice, though optogenetic inhibition of dmPFC-DMS projections in WT mice was sufficient to induce increased grooming. c Ketamine blocks the increase in grooming behavior induced by optogenetic inhibition of dmPFC-DMS projection in KO mice.

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