Table 1 Summary of effects on DPRs with eif-2D/eIF2D decrease.

From: A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

Species

G4C2 repeats

eIF2D

Poly-GA

Poly-GP

Poly-GR

C. elegans

Monocistronic construct, 75 G4C2

Null allele

↓↓

↓

NS

NSC34 cells

Monocistronic construct, 75 G4C2

KD

↓↓

NS

NS

HEK293 cells

Bicistronic construct, 75 G4C2

KD

↓↓

↓↓

↓↓

iPSC-derived motor neurons

Endogenous C9ORF72 locus, >24 G4C2

KD

ND

NS

NS

  1. ↓↓: >50% decrease.
  2. ↓: <50% decrease.
  3. KD knockdown, NS not significant, ND not detected.
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