Fig. 5: Dynamics of sphingolipids in the aging mouse brain. | Nature Communications

Fig. 5: Dynamics of sphingolipids in the aging mouse brain.

From: A metabolome atlas of the aging mouse brain

Fig. 5

a Heatmaps with fold-changes for HexCer, sHexCer, and SM sphingolipids in brain regions between early adult versus adolescent, middle-age versus early adult, and old age versus middle age. b Pathways of HexCer, sHexCer, and SM biosynthesis. HexCer, sHexCer, and SM are highly enriched in oligodendrocyte or myelin. c Simplified scheme summarizing myelin sphingolipid changes during brain aging. Very-long-chain sphingolipids increasing from adolescent to middle-aged brains with a subsequent decrease from towards old age. Long-chain sphingolipids almost keep constant levels across all age groups.

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