Fig. 5: Clustered BIA genes are co-regulated and evolved in a coordinated manner. | Nature Communications

Fig. 5: Clustered BIA genes are co-regulated and evolved in a coordinated manner.

From: Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway

Fig. 5

a The heatmap of the average normalized expression level of genes at the donor and the recipient loci related with STORR in six tissues of three Papaver species. Details of the gene expressions related to BIA genes were shown in Supplementary Fig. 38. b Hi-C interaction heatmap of regions including two copies of morphinan gene cluster on chr15 (top) and chr8 (down) of P. setigerum, shown at a resolution of 10 kb. The morphinan branch gene regions are marked with colored boxes. c The comparison of the interactions between two morphinan gene copies in P. setigerum. The p-value is calculated by a two-sided Wilcoxon rank-sum test. For the boxplot, the centerline, median; box limits, upper and lower quartiles; whiskers, data range. n is the number of bins. d Dotplots of STORR, SALSYN, SALAT, SALR, and THS promoter sequences between P. somniferum (one copy) and P. setigerum (two copies). Promoter is defined as 2 kb upstream region of the transcription start site. Source data are provided as a Source Data file.

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