Fig. 2: Identification of malignant thyrocytes and their transcriptional heterogeneity between different tissue types. | Nature Communications

Fig. 2: Identification of malignant thyrocytes and their transcriptional heterogeneity between different tissue types.

From: Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma

Fig. 2

UMAP projection of 36,265 thyrocytes colored by (a) cluster and (b) tissue. c Heatmap of pair-wise Spearman’s correlations among c01-c09 thyrocyte clusters. Boxplots showing TDS scores of (d) each thyrocyte cluster and (e) tissue type. The number of cells in each group is shown in Supplementary Table 4. The middle lines of the boxplots show the median (central line), the lower and upper hinges show the 25–75% interquartile range (IQR), and the whiskers extend from the hinge to the farthest data point within a maximum of 1.5x IQR. Heatmaps of the top DEGs between (f) malignant versus non-malignant thyrocytes, (g) tumor-derived versus LN-derived malignant thyrocytes, and (h) tumor-derived versus subcutaneous loci-derived malignant thyrocytes. Source data are provided in the Source data file.

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