Fig. 2: Itgβ8 expression on Tregs promotes tumor growth.
From: Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation
Foxp3ΔItgβ8 mice in red and their littermate controls in black (Foxp3Ctrl) were injected either i.d. with melanoma (B16 cells) or in the mammary gland with breast cancer (E0771 cells). a, b Representative graphs illustrating the size of the tumors at different days post-injection. n = 5–8 mice per group. Data representative of two independent experiments. c, d Graphs demonstrate the tumor size (mean ± SD), at the day of the euthanasia (18 days after injections) of the two independent experiments with a total of 16 mice per group. c P = 0.0018, d P = 0.0001. ***P < 0.001 and **P < 0.01 were determined by unpaired two-tailed Student t test. e, f Representative pictures of tumors at the end of the experiments. Source data are provided as a Source Data file.
