Table 1 Absence of Itgβ8 on Tregs represses tumor growth.

From: Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

 

Melanoma

Breast cancer

Genotype

Foxp3Ctr

Foxp3ΔItgβ8

Foxp3Ctr

Foxp3ΔItgβ8

Number of mice

16

16

16

16

Number of mice with non-measurable tumor

0

4

1

8

Percentage of mice with non-measurable tumor

(0%)

(25%)

(6.25%)

(50%)

  1. Foxp3ΔItgβ8 mice and their littermate controls (Foxp3Ctrl) were injected either i.d. with melanoma (B16 cells) or in the mammary gland with breast cancer (E0771 cells). Table showing the percentage of Foxp3ΔItgβ8 mice and Foxp3WT mice with a completed control of tumor growth (tumor < 100 mm3 all along the experiments) for both melanoma and breast cancer 18 days after implantation.
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