Fig. 9: Computational simulation confirms that directed transport is required to disperse mRNA in myofibers.
From: Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle
A Diagram of RNA mobility states modeled in the simulation of RNA motion in myofibers. B Network diagram of the discrete-time Markov chain (DTMC) model developed to simulate RNA generation, motion, and decay. C Comparison of RNA localization patterns observed in 1000 h simulations of Polr2a RNA either with or without directed transport states. D Distance to nucleus measured for simulated Polr2a RNAs with (orange) or without (blue) directed transport states. Shown for comparison is the distribution from a simulation of Polr2a mRNAs in the high-mobility diffusion state (green) and a null distribution generated from randomly selected cytoplasmic coordinates (gray).
