Table 1 Clinical demographics for suspected CLL cases with Xq28 rearrangements.
From: Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
Age (years) | Sex | Diagnosis | IGHV | Treated | Complexity | Karyotypea |
|---|---|---|---|---|---|---|
59A | F | CLL | Unmutated | No | 2 | 47,XX,+12[17]/47,idem,t(X;14)(q28;q32)[2]/46,XX[2].ish t(X;14)(5’ IGH+;3’ IGH+) |
59 | F | CLL | ND | Yes | 3 | 46,X,t(X;12)(q28;q13),t(3;19)(q28;q13.1),add(20)(q11.2)[9]/46,XX[10]/nonclonal[2].ish t(3;19)(BCL6+, BCL3+;BCL6−,BCL3−) |
71 | M | CLL | Unmutated | yes | >6 | 46,XY,del(6)(q13)[cp2]/45,sl,der(6)ins(6;?)(p21;?)del(6)(q21),der(8)t(8;15)(p21;q15),-15,idic(16)(p11.2),add(17)(p11.2)[cp19]/45,t(X;12)(q28;q13),-Y,+8,add(9)(q22),del(11)(q21),-22[cp2]/46,XY[2] /nonclonal[1].ish add(17)(TP53−) |
74 | F | CLL | Mutated | Yes | 4 | 46,XX,del(6)(q15q21)[9]/46,idem,t(X;8)(q28;q22),inv(11)(p15q23)[cp3,one is 4n]/nonclonal w/clonal abnormalities[1]/46,XX[16] |
59 | M | Diffuse Large B-Cell Lymphoma | ND | No | >6 | 47,XY,der(X)t(X;8)(q28;q24.2)ins(X;?)(q28;?),dup(1)(q21q42),dup(2)(q31q35),t(3;9)(q27;q32),del(7)(q22q32),der(8)t(X;8)(q28;q24.2),+12,der(12)t(12;13)(q24.3;q22)x2,der(13)t(12;13)(q24.3;q12),t(14;19)(q32.3;q13.2)[cp16]/53,sl,+der(X)t(X;8)ins(X;?),+4,+5,+del(7),+11,+der(12)t(12;13)[cp3]/46,XX[1] |
60 | M | CLL | Unmutated | Yes | >6 | 44,XY,del(9)(p22),psu dic(17;6)(p13;q21),dic(18;20)(p11.2;p11.2)[11]/45,sl,add(X)(q28),+add(9)(p22),-del(9)(p22),dic(15;21)(p11.2;p11.2),+18,-dic(18;20),+20,+mar1[2]/90-91,sdl1x2,+add(X),+add(X),-Y,add(9)(q22)x4,-add(9)(p22),-add(9)(p22),+mar2[2]/44,sl,del(13)(q12q21.2)[5]/nonclonal w/clonal abnormalities[1] |
64 | F | CLL | Unmutated | yes | >6 | 60–79<4n>,XX,-X,-X,add(1)(q21)x2,add(3)(q29)x2,-4,-4,-6,-6,-8,-8,-9,-9,-13,-13,-14,psu dic(17;5)(p11.2;p13)x2,-18,add(18)(q23)x2,+mar1,+mar2x2[cp4]/72-80,sl,add(20)(q13.3),-mar1,+mar4[cp7]/58-78,sdl1,add(X)(q28)[cp2]/84-94,sdl1,+2,+7,+16,+19[cp2]/nonclonal w/ clonal abnormalities[5] |
56 | M | CLL | Unmutated | no | 4 | 45,Y,der(X)(Xpter->Xq28::11q12->11q13::1q32->1qter),der(1)t(1;11)(q32;q13),der(11)(?::11p15.5->11q12::Xq28->Xqter),-21[cp2]/46,XY[16]/nonclonal[4].ish der(X)(CCND1+),der(1)(ATM+) |
