Fig. 2: Cryo-EM structure of the G51D α-syn fibril.
From: The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein
a Cryo-EM density map of G51D α-syn fibril. Fibril parameters including half-pitch, twist angle, and rise are marked. The two protofilaments are colored in medium purple and forest green, respectively. The map was prepared by UCSF Chimera v1.13. b Cross-section view of the density map with a built-in structure model. c The protofilament interface of G51D fibril is shown in sticks. Residues involved in the inter-protofilament interactions are indicated in spheres. d Views of six layers of G51D α-syn fibrils are shown in the cartoon. The fibril axis is indicated. The β-strands are numbered and labeled accordingly.
