Fig. 6: Immunofluorescence staining confirms elevated expression of PLAU and DPP4 in human and mouse skin and scar. | Nature Communications

Fig. 6: Immunofluorescence staining confirms elevated expression of PLAU and DPP4 in human and mouse skin and scar.

From: The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation

Fig. 6

A H&E staining of human skin and scar; immunofluorescent staining of B Urokinase and C DPP4 in human skin and scar. Quantification of staining intensity separate for epidermis and dermis for D urokinase (p = 0.329 dermis, p = 0.815 epidermis) and E DPP4 (p < 0.0001 dermis, p < 0.0001 epidermis). For all stainings, n = 2–3 normal skin samples were analyzed, and n = 4 scars. From each sample, five regions of interest per sample were quantified. ELISA from human whole skin (n = 6) and scar (n = 6) lysate for F urokinase (p < 0.0001) and G DPP4 (p = 0.0037) is shown. Statistical significance was tested using two-tailed unpaired Student t-test. Lines and error bars indicate mean and standard deviation. NS p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001. Source data are provided as a Source data file.

Back to article page